Anti-Id2 antibody produced in rabbit，100UG，SAB4300701-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Id2 (inhibitor of DNA binding 2) belongs to the HLH (helix–loop–helix) family. It is located on human chromosome 2p25.
The antibody detects endogenous level of total Id2 protein.

Immunogen

Peptide sequence around aa. 5-9 (S-P-V-R-S), according to the protein NP_002157.2

Biochem/physiol Actions

Id2 (inhibitor of DNA binding 2) knockdown decreases the upregulation of N-cadherin, vimentin and Snail and promotes the expression of E-cadherin. It has the ability to interact with Rb protein and block its antiproliferative activity. It can prevent the separation of cells, stimulate multiplication of cell and help in reprogramming of Hodgkin lymphoma cells, the oncogenic AP-1 transcription factor FRA2 (fos-related antigen 2) and the oncogenic tyrosine kinase CSF-1 receptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~15 kDa
species reactivity	rat, mouse, human
concentration	1 mg/mL
technique(s)	western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(S-P-V-R-S)
NCBI accession no.	NM_002166.4
UniProt accession no.	Q02363
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... Id2(3398)

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