Mpro, 3CL Protease from coronavirus SARS，100MIG，SAE0224-100UG，Sigma

General description

Mpro, 3CL is a critical enzyme for the coronavirus life cycle. It activity yield non-structural proteins that are crucial for genome replication and Coronavirus virion production: RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). The maturation of SARS coronavirus depends on cleavage of the overlapping large polyproteins 1a and 1ab by two viral proteases:

• Mpro (main protease)
• PLpro (Papain-like protease)

Features and Benefits

Mpro, 3CL Protease (3C-like protease) is the main protease of Human SARS Coronavirus.

Mpro 3CL Protease is a cysteine protease. Mpro protease cleaves proteins with sequences including LQ[S/A/G) c-terminal to the glutamine residue.

Physical form

The product is supplied lyophilized from 20 mM HEPES, 2.5% Trehalose, and 0.05% Tween 20.


This product contains the complete sequence of Mpro protease [Uniprot No.: P0C6U8 (3241-3546)] without any additional tags. The product is supplied lyophilized from 20 mM HEPES, 2.5% Trehalose, and 0.05% Tween 20.