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Biochem/physiol Actions
Survivin expression inhibitor with anti-cancer efficacy in cultures and in vivo.
YM155 is a survivin expression inhibitor (effective conc. 10-100 nM for 6-48h; PC-3 & PCC-1 cells) that induces apoptosis in malignant melanoma and hormone-refractory prostate cancer (HRPC) cultures (GI50 = 2.3-11 nM) by targeting survivin gene promoter activity without affecting the expression of other IAPs or Bcl-2-related proteins even at concentrations as high as 100 nM. In a s.c. xenografted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression in vivo.
Disclaimer
Hygroscopic
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | -10 to -25°C |
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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