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Biochem/physiol Actions
Inhibitor of CARP-1(CCAR1)-NEMO interaction that binds to CARP-1 and potentiates chemotherapeutic effects of DNA damaging agents
SNI-1 is an inhibitor of CARP-1(CCAR1)-NEMO (NF-κB essential modulator) interaction that binds to CARP-1. SNI-1 inhibits chemotherapy-dependent canonical NF-κB signaling and attenuates secretion of the pro-inflammatory cytokines TNFα, IL-1β, and IL-8. It potentiates chemotherapeutic effects of DNA damaging agents such as Cisplatin and Adriamycin (doxorubicin) in several cancer cell lines including human triple-negative breast cancer (TNBC).
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC1=CC=C(C=C1)N2C(SCC(C3=CC(O)=C(C=C3)O)=O)=NN=N2 |
| InChI key | MVIWFFDPSPYDKQ-UHFFFAOYSA-N |
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 775.42
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