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- 包装参数
General description
Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.
Biochem/physiol Actions
MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.
Physical form
Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.
Other Notes
One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.
Legal Information
Brij is a registered trademark of Croda International PLC
| recombinant | expressed in E. coli |
| Quality Segment | 200 |
| assay | ≥95% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | calculated mol wt 20.3 kDa |
| UniProt accession no. | P39900 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... MMP12(4321) |
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¥ 1563.36
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