- 商品介绍
- 规格参数
- 包装参数
Application
Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2.
Biochem/physiol Actions
Desmosterol Delta24 (D24) reductase inhibitor.
Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.
Preparation Note
Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| color | white to off-white |
| mp | 102.9-103.7 °C |
| solubility | DMSO: 20 mg/mL,H2O: insoluble,alcohol: soluble,olive oil: slightly soluble |
| storage temp. | 2-8°C |
| SMILES string | CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3 |
| InChI | 1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3 |
| InChI key | SYHDSBBKRLVLFF-UHFFFAOYSA-N |
| Gene Information | human ... DHCR24(1718), EBP(10682) |
| 长度(mm) | |
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