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General description
TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.
Biochem/physiol Actions
TIC10 (TRAIL-inducing compound 10) induces apoptosis mediated by TRAIL (TNF-related apoptosis-inducing ligand) in a number of cancers without toxicity such as breast, colon and glioblastoma multiforme tumors.
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers.
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 5 mg/mL, clear |
| storage temp. | 2-8°C |
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¥ 2622.09
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¥ 3372.68
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¥ 4897.21
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¥ 4404.38
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¥ 5061.38
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¥ 2132.12
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¥ 3031.24
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¥ 954.17
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¥ 8072.66
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