BAY-0069，5MG，SML3733-5MG，Sigma

Biochem/physiol Actions

BAY-0069 is a potent and selective covalent PPARγ inverse agonist (IC50 = 0.22 nM, max inhibition = 88% by cell-based reporter assays) that induces interactions between the PPARγ ligand-binding domain (LBD) and the corepressor NCOR2 (EC50 = 9.6 nM, Emax = 620% by TR-FRET). BAY-0069 exhibits anti-proliferation efficacy against PPARγ-dependent growth in cultures (UM-UC9 IC50 = 2.5 nM, max inhibition = 72%).
Potent and selective covalent PPARγ inverse agonist with anti-proliferation efficacy against PPARγ-dependent growth in cultures.