[KO Validated]Anti-Stat3 antibody produced in mouse,1004G,SAB1309052-100UL,Sigma

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订货号 0BU3304
品牌型号 Sigma SAB1309052-100UL
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).


Biochem/physiol Actions

This Stat3 antibody is generated from a mouse immunized with Stat3 recombinant protein.


Physical form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.


技术参数 Specifications
biological source (Human)
conjugateunconjugated
antibody formpurified antibody
antibody product typeprimary antibodies
clonemonoclonal
formliquid
mol wt 28303Da
species reactivityhuman
technique(s)western blot: 1:2000
isotypeIgG2a, kappa
NCBI accession no. P42227, Q19S50,P52631
storage temp.-10 to -25°C
target post-translational modificationunmodified
Gene Informationhuman ... STAT3(6774)
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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