- 商品介绍
- 规格参数
- 包装参数
Application
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Biochem/physiol Actions
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
Preparation Note
TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >10 mg/mL |
| web metadata keyword.default | Cholest-4-en-3-one oxime CAS 22033-87-0,NSC 21311 Olesoxime for peripheral neuropathy,TRO 19622 DMSO soluble compound,TRO 19622 Neuroscience small molecule,TRO 19622 Olesoxime neuroscience research,TRO 19622 for myelin repair in rat models,TRO 19622 for neuropathic pain research,TRO 19622 for tactile allodynia studies,TRO 19622 in vivo studies for diabetes,TRO 19622 mitochondrial permeability transition pore inhibitor,TRO 19622 neuroprotective agent,TRO 19622 research grade,TRO 19622 stock solution preparation,TRO 19622 |
| storage temp. | −20°C |
| InChI | 1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+ |
| InChI key | QNTASHOAVRSLMD-SGWCAAJKSA-N |
| 长度(mm) | |
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| 重量(kg) |
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