Anti-Sodium Channel NaV1.8 antibody produced in rabbit,200UL,S2071-200UL,Sigma

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订货号 0BT8673
品牌型号 Sigma S2071-200UL
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Anti-Sodium Channel NaV1.8 specifically recognizes NaV1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the
Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2.


Immunogen

peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Nav1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human.


Application

Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry.


Biochem/physiol Actions

Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis).


Physical form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide.


Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


技术参数 Specifications
biological sourcerabbit
Quality Segment200
conjugateunconjugated
antibody formaffinity isolated antibody
antibody product typeprimary antibodies
clonepolyclonal
formlyophilized powder
species reactivityrat
technique(s)immunohistochemistry (frozen sections): suitable using adult rat DRG,western blot: 1:200 using rat DRG lysates
UniProt accession no.Q62968
shipped inwet ice
storage temp.−20°C
target post-translational modificationunmodified
Gene Informationhuman ... SCN10A(6336)
mouse ... Scn10a(20264)
rat ... Scn10a(29571)
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