- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
IMS2186 is an anti-proliferative and anti-angiogenic.
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | desiccated |
| color | white to off-white |
| solubility | DMSO: >20 mg/mL |
| storage temp. | room temp |
| SMILES string | COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O |
| InChI | 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+ |
| InChI key | BZCADTHMZLYKAR-MDWZMJQESA-N |
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¥ 2707.32
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¥ 2528.88
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¥ 2013.69
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¥ 1779.22
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¥ 3372.68
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¥ 15214.65
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¥ 1301.36
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