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Biochem/physiol Actions
Cancer tissue-targeting photosensitizer that induces irradiation-dependent cancer killing and in vivo photodynamic therapy (PDT) efficacy.
Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).
Disclaimer
Hygroscopic
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | , Dark green to black |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(C[C@H](NC(C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C(C(O[Na])=O)=C1N5)C)=N\2)=O)C(O[Na])=O)O[Na] |
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¥ 1866.29
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¥ 5887.85
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¥ 5725.45
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¥ 3290.05
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¥ 2151.46
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¥ 1509.00
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