- 商品介绍
- 规格参数
- 包装参数
Application
VU591 may be used in cell signaling studies.
Biochem/physiol Actions
ROMK (Kir 1.1) inhibitor
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥12 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | [O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1 |
| InChI | 1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20) |
| InChI key | ZQPXNYLXYNRFNP-UHFFFAOYSA-N |
| Gene Information | human ... KCNJ1(3758) |
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