TAU-441, GSK3BETA-Phosphorylated，50UG，SRP0689-50UG，Sigma

销售价： ¥ 5007.69 / 件

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订货号： 0BT7221

品牌型号： Sigma SRP0689-50UG

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最小订货量： 1件

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产品介绍 Product Description

Biochem/physiol Actions

Recombinant human tag-free Tau-441 was co-expressed with GSK3beta in E. coli cells. The Tau-441 protein was phosphorylated by GSK3beta in vivo and in vitro prior to the final chromatography purification. Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules ⁽¹⁾. Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system ⁽²⁾.

Preparation Note

Formulated in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
Store in aliquots at -70°C. Avoid freeze/thaw cycles.

技术参数 Specifications

recombinant	expressed in E. coli
assay	70-95% (SDS-PAGE)
form	frozen liquid
mol wt	~64-68 kDa
concentration	0.2 μg/μL
accession no.	P10636-8
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... MAPT(4137)

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