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Biochem/physiol Actions
CGP36742 is a GABAB receptor antagonist.
CGP36742 was the first orally active GABAB-selective antagonist. The IC50 for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Segment | 100 |
| assay | ≥97% (NMR) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 10 mg/mL (clear solution, warmed) |
| storage temp. | room temp |
| SMILES string | CCCCP(O)(=O)CCCN |
| InChI | 1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10) |
| InChI key | ONNMDRQRSGKZCN-UHFFFAOYSA-N |
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