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General description
Research Area: Cell Signaling
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Application
L-Lactic Dehydrogenase from bovine muscle has been used in lactate assay to assess lactate tissue accumulation.
Biochem/physiol Actions
Lactate dehydrogenase (LDH) plays a critical role as a checkpoint in gluconeogenesis and DNA metabolism. It plays a vital role in maintaining homeostasis during periods of low oxygen availability. As an oxidoreductase enzyme, lactate dehydrogenase catalyzes the reversible conversion of pyruvate to lactate using NADH. This enzyme is crucial for the anaerobic metabolism of glucose when oxygen is either absent or in short supply. LDH is the sole serum biomarker effective for evaluating metastatic melanomas.
Also catalyzes the oxidation of other
Physical form
Crystalline suspension in 2.4 M (NH4)2SO4 solution, pH 6.0
Analysis Note
Protein determined by biuret.
Other Notes
One unit will reduce 1.0 μmole of pyruvate to
| biological source | bovine muscle |
| Quality Level | 200 |
| type | Type X |
| assay | 3.0—25.0 mg protein/mL (biuret) |
| form | ammonium sulfate suspension |
| specific activity | ≥600 units/mg protein |
| manufacturer/tradename | Sigma-Aldrich |
| technique(s) | activity assay: suitable |
| color | white |
| pH | 7.5 |
| UniProt accession no. | P19858,Q5E9B1 |
| application(s) | life science and biopharma |
| foreign activity | pyruvate kinase ≤0.01% |
| storage temp. | 2-8°C |
| Gene Information | cow ... LDHA(281274), LDHB(281275) |
| 长度(mm) | |
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| 重量(kg) |
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¥ 916.08
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¥ 625.35
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¥ 3317.36
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¥ 860.58
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔
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