- 商品介绍
- 规格参数
- 包装参数
General description
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
Application
CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
Biochem/physiol Actions
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
Positive AMPA glutamate receptor modulator.
Disclaimer
Photosensitive
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | protect from light |
| color | white to off-white |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | O=C(N1CCCCC1)c2ccc3OCCOc3c2 |
| InChI | 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2 |
| InChI key | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
| Gene Information | human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) |
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