- 商品介绍
- 规格参数
- 包装参数
Application
CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
Biochem/physiol Actions
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.
Potent 5-lipoxygenase inhibitor
Features and Benefits
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to tan |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2 |
| InChI | 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26) |
| InChI key | VPTONMHDLLMOOV-UHFFFAOYSA-N |
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