- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I interferon in primary macrophages from Trex1 null mice. Ru.521 binds to the CGAS catalytic pocket and inhibits dsDNA-induced cGAS-mediated interferon upregulation.
RU.521 helps to understand the biological functions of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) synthase. It can act as a molecular scaffold for developing future autoimmune therapies. RU.521 can also inhibit the inflammatory cytokine expression induced by Aspergillus fumigatus.
potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Clc1c2nc([nH]c2ccc1Cl)[n]3nc(c(c3O)C4OC(=O)c5c4cccc5)C |
| InChI | 1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,26H,1H3,(H,22,23) |
| InChI key | VIQXILLOJLATEF-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1779.22
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 2617.87
-
询价
-
¥ 56581.65
-
¥ 18741.69
-
¥ 26846.31
-
¥ 51018.02
-
询价
-
¥ 39676.71
-
¥ 15894.19
-
¥ 402833.12
-
询价
-
询价
微信小程序
7X24小时在线咨询