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Biochem/physiol Actions
VU041 is a mosquito cuticle penetrant, potent and selective inhibitor of inwardly rectifying potassium (Kir) channel of Aedes aegypti (AeKir1) and Anopheles gambiae (AnKir1) that exhibits potent toxicity to adult insecticide-susceptible and -resistant strains of female mosquitoes. VU041 is selective for mosquito Kir channels over several mammalian orthologs. Also, VU041 is toxic to mosquito larvae when present in water.
mosquito cuticle penetrant, potent and selective inhibitor of Kir channel of Aedes aegypti and Anopheles gambiae; selective for mosquito Kir channels over several mammalian orthologs
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(CN1N=C(C2=C1CCCC2)C(F)(F)F)N3CCCC4=C3C=CC=C4 |
| InChI | 1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2 |
| InChI key | DLAGRCZUELSZFG-UHFFFAOYSA-N |
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¥ 2290.21
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¥ 1779.22
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¥ 2068.25
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¥ 2883.61
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¥ 20380.83
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¥ 2151.46
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¥ 1509.00
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¥ 1156.91
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¥ 3852.13
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¥ 1783.21
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¥ 2288.54
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¥ 5990.26
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