PPAR， γ 人，10UG，SRP2045-10UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPAR α is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR β is found in many tissues but the highest expression is in the gut, kidney and heart. PPAR γ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. The target genes of PPAR α are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

技术参数 Specifications

biological source	human
recombinant	expressed in E. coli
assay	≥70% (SDS-PAGE)
form	frozen liquid
mol wt	~60 kDa
packaging	pkg of 10 μg
storage condition	avoid repeated freeze/thaw cycles
concentration	500 μg/mL
technique(s)	ligand binding assay: suitable
color	clear colorless
NCBI accession no.	NM_138712
UniProt accession no.	P37231
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... PPARG(5468)

长度(mm)
宽度(mm)
高度(mm)
重量(kg)