KD-Validated Anti Methyl-CpG Binding Domain Protein 1 Antibody, clone 24GB405, Rabbit Monoclonal，1004G，SAB6012402-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
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Immunogen

A synthesized peptide corresponding to a sequence within amino acids 550-605 of human MBD1 [NP_056671.2].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

技术参数 Specifications

biological source	rabbit (Monoclonal)
Quality Segment	100
recombinant	expressed in HEK 293 cells
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	24GB405, recombinant monoclonal
form	buffered aqueous glycerol solution
mol wt	67 kDa
species reactivity	human
packaging	vial of 1.5 mL
enhanced validation	recombinant expression Learn more about Antibody Enhanced Validation
sustainability	Greener Alternative Product
concentration	0.5 mg/ml
technique(s)	western blot: 1:1,000-1:5,000
isotype	IgG
Ensembl \| human accession no.	ENSG00000141644
NCBI accession no.	NP_056671.2
UniProt accession no.	Q9UIS9
greener alternative category	DfS-Developed
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MBD1(4152)

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