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Biochem/physiol Actions
(S)-CPP is an inhibitor of branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, also know as BDK, or keto acid dehydrogenase kinase. BDK is a negative regulator of BCKDC activity. Inhibition of BDK by (S)-CPP (IC50 = 6.3 μM) leads to complex activation, and significant reduction of plasma levels of leucine/isoleucine and valine in wild type mice.
(S)-CPP is an inhibitor of branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, also know as BDK, or keto acid dehydrogenase kinase.
| Quality Segment | 100 |
| assay | ≥96% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | H2O: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [O-]C([C@@H](Cl)CC1=CC=CC=C1)=O.[Na+] |
| InChI | 1S/C9H9ClO2.Na/c10-8(9(11)12)6-7-4-2-1-3-5-7;/h1-5,8H,6H2,(H,11,12);/q;+1/p-1/t8-;/m0./s1 |
| InChI key | HMHPCHNNVOLTFC-QRPNPIFTSA-M |
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¥ 2707.32
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¥ 6894.69
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¥ 8135.09
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¥ 4404.38
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¥ 20380.83
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¥ 5061.38
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