- 商品介绍
- 规格参数
- 包装参数
General description
CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.
Immunogen
peptide corresponding to amino acids residues 1315-1331 of human Caspr2.
Application
Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:200 by using rat brain membranes.
Biochem/physiol Actions
CASPR2 (Contactin-associated protein-like 2) associates shaker like K+ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse formation and outgrowth of axon and dendrite. CASPR2 forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.
Physical form
Lyophilized from 0.4 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and ≤0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| mol wt | antigen 180 kDa |
| species reactivity | mouse, rat, human |
| technique(s) | immunohistochemistry: suitable,western blot: 1:200 using rat brain membranes |
| UniProt accession no. | Q9UHC6 |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CNTNAP2(26047) mouse ... Cntnap2(66797) rat ... Cntnap2(500105) |
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¥ 1148.92
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¥ 2622.09
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¥ 1596.77
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¥ 2883.61
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¥ 3812.28
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¥ 10277.12
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