Anti-TCF12 antibody produced in rabbit，100UG，SAB3500566-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3.

Immunogen

TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12.

Application

Anti-TCF12 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500566.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
species reactivity	human, mouse, rat
technique(s)	immunocytochemistry: suitable,indirect ELISA: suitable,western blot: suitable
NCBI accession no.	AAH50556
UniProt accession no.	Q99081
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... TCF12(6938)

长度(mm)
宽度(mm)
高度(mm)
重量(kg)