Anti-phospho-IR (pTyr¹³⁵⁵) antibody produced in rabbit，100UG，SAB4503924-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.

Immunogen

The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.

Immunogen Range: 1326-1375

Biochem/physiol Actions

Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen 156 kDa
species reactivity	mouse, rat, human
concentration	~1 mg/mL
technique(s)	ELISA: 1:10000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000
NCBI accession no.	P06213
UniProt accession no.	P06213
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pTyr1355)
Gene Information	human ... INSR(3643)

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