- 商品介绍
- 规格参数
- 包装参数
Application
MC2050 hydrate may be used in cell signaling studies.
Biochem/physiol Actions
MC2050 is a PARP-1 inhibitor
MC2050 is a water-soluble PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | H2O: ≥5 mg/mL at warmed to 60 °C |
| storage temp. | 2-8°C |
| SMILES string | O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14 |
| InChI | 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2 |
| InChI key | LMZZPRHHBPFDGE-UHFFFAOYSA-N |
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