- 商品介绍
- 规格参数
- 包装参数
General description
Piericidin A, an antibiotic isolated from Streptomyces mobaraensis, features a 4-pyridinol core linked with a methylated polyketide side chain, closely resembling coenzyme Q (ubiquinone) in structure.
Application
Piericidin A solution may be used as a control agent for soft rot disease in potato tubers and to evaluate its effects on the expression of virulence genes in Erwinia carotovora. It may also be used as an inhibitor of mitochondrial complex I to study its effects on gluconeogenesis and glucose-lowering mechanisms in the context of metformin and other guanides/biguanides in both in vitro and in vivo experiments.
Biochem/physiol Actions
Piericidin A is a potent irreversible inhibitor of mitochondrial complex I (NADH:ubiquinone oxidoreductase). Piericidin A potently binds to ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. Piericidin A exerts its inhibitory effects by binding to the ubiquinone binding site of complex I, effectively blocking the translocation of protons across the mitochondrial membrane.
| description | Piericidin A 1% Solution in Ethanol,1%in Ethanol |
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solution |
| concentration | 10 mg/mL |
| color | colorless to yellow |
| storage temp. | -10 to -25°C |
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¥ 1082.93
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¥ 1756.15
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¥ 1137.02
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¥ 1066.63
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¥ 2005.84
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¥ 1212.50
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¥ 1390.75
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¥ 1518.67
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