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Biochem/physiol Actions
Potent ATP-competitive inhibitor against DDR1, DDR2; MAPK11 (p38β), and MAPK14 (p38α) with good cellular target actviity and kinome selectivity.
SR-302 is an ATP-competitive, potent and selective inhibitor against DDR1/2 & MAPK11/14 (IC50/[ATP] = 53.3 nM/100 μM/DDR1, 0.75 nM/5 μM/DDR2; 45.1 nM/50 μM/MAPK11 (p38β), 6.2 nM/2.5 μM/MAPK14 (p38α) by cell-free kinase assay) with good cellular target actviity (IC50 = 18 nM/DDR2, 23 nM/DDR1, 125 nM/MAPK14, 196 nM/MAPK11 by NanoBRET) and kinome selectivity.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(NCC1=CC=C(C=C1)C(N[C@H](C(NC2CN(CCC2)S(=O)(C)=O)=O)CCC3CCCCC3)=O)C4=CN=C5C=CC=CN54 |
| InChI | 1S/C32H42N6O5S/c1-44(42,43)37-18-7-10-26(22-37)35-31(40)27(17-14-23-8-3-2-4-9-23)36-30(39)25-15-12-24(13-16-25)20-34-32(41)28-21-33-29-11-5-6-19-38(28)29/h5-6,11-13,15-16,19,21,23,26-27H,2-4,7-10,14,17-18,20,22H2,1H3,(H,34,41)(H,35,40)(H,36,39)/t26?,27-/m |
| InChI key | WGMNFJAFXXXRLZ-GEVKEYJPSA-N |
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¥ 2528.88
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¥ 2068.25
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¥ 3275.78
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¥ 4897.21
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¥ 3319.60
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