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General description
A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
platelet integrin →IIb→3
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
FEEERA
Shen, B., et al. 2013. Nature503, 131.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| assay | ≥98% (HPLC) |
| Quality Segment | 100 |
| form | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | white |
| solubility | DMSO: 100 mg/mL |
| storage temp. | −70°C |
| 长度(mm) | |
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¥ 2528.88
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¥ 1573.49
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¥ 6894.69
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¥ 15214.65
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¥ 2882.02
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¥ 3319.60
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¥ 2617.87
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¥ 5014.59
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¥ 2911.61
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¥ 10685.48
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