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Biochem/physiol Actions
IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.
Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.
| biological source | human |
| Quality Level | 200 |
| recombinant | expressed in E. coli |
| assay | ≥97% (SDS-PAGE) |
| form | lyophilized powder |
| potency | <10.000 ng/mL ED50 |
| mol wt | 12 kDa |
| packaging | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities | endotoxin, tested |
| color | white |
| UniProt accession no. | P35225 |
| storage temp. | −20°C |
| Gene Information | human ... IL13(3596) |
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