Monoclonal Anti-SCN8A antibody produced in mouse，100UG，WH0006334M4-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Sodium voltage-gated channel αsubunit 8 (SCN8A) is expressed in the central nervous system. The protein is specifically expressed in the axonal initial segment (AIS) and the nodes of Ranvier of myelinated axons. The gene encoding SCN8A is localized on human chromosome 12q13.13.

Immunogen

SCN8A (NP_055006, 1854 a.a. ~ 1951 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT

Biochem/physiol Actions

Sodium voltage-gated channel αsubunit 8 (SCN8A) has a role in the generation and conduction of action potential. Mutations in the SCN8A gene have been associated with early infantile epileptic encephalopathy type 13.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	4G7, monoclonal
form	buffered aqueous solution
species reactivity	rat, mouse, human
technique(s)	indirect ELISA: suitable,indirect immunofluorescence: suitable,western blot: 1-5 μg/mL
isotype	IgG2aκ
GenBank accession no.	NM_014191
UniProt accession no.	Q9UQD0
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... SCN8A(6334)

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