- 商品介绍
- 规格参数
- 包装参数
Application
Dp44mT may be used in cell signaling studies.
Biochem/physiol Actions
Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.
Cell-permeable iron chelator and top2a activity inhibitor
Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Disclaimer
Material appears to be unstable in solution; make solutions immediately before use.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | yellow to orange |
| solubility | DMSO: ≥5 mg/mL |
| originator | Bayer |
| storage temp. | 2-8°C |
| SMILES string | CN(C)C(=S)N\N=C(\c1ccccn1)c2ccccn2 |
| InChI | 1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20) |
| InChI key | XOBIGRNRXCAMJQ-UHFFFAOYSA-N |
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