- 商品介绍
- 规格参数
- 包装参数
Application
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
Biochem/physiol Actions
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | protect from light |
| color | red |
| solubility | DMSO: ≥10 mg/mL,H2O: insoluble |
| storage temp. | 2-8°C |
| SMILES string | ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O |
| InChI | 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
| InChI key | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
| Gene Information | human ... CDC25B(994), DUSP3(1845), PTPN1(5770) |
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¥ 1866.29
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¥ 4173.75
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔询价
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