- 商品介绍
- 规格参数
- 包装参数
General description
The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Immunogen
Human epidermoid carcinoma line A431
Biochem/physiol Actions
The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.
Physical form
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preparation Note
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | phycoerythrin (R-PE) conjugate |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | EGFR1, monoclonal |
| form | buffered aqueous solution |
| species reactivity | horse, ( Human) |
| technique(s) | flow cytometry: suitable |
| isotype | IgG2bκ |
| UniProt accession no. | P00533 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... EGFR(1956) |
| 长度(mm) | |
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¥ 2528.88
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¥ 4164.19
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¥ 2814.26
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¥ 2068.25
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¥ 5725.45
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¥ 2268.97
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