- 商品介绍
- 规格参数
- 包装参数
Application
MS-1020 may be used in JAK-3-mediated cell signaling studies.
Biochem/physiol Actions
MS-1020 is a selective JAK3 inhibitor
MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression.
Features and Benefits
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥10 mg/mL at 60 °C |
| storage temp. | 2-8°C |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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