- 商品介绍
- 规格参数
- 包装参数
Application
PSB-12062 has been used as a P2X4 antagonist to pre-treat macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-treat P2X7-deficient BV-2 cells to elucidate the roles of P2X4.
Biochem/physiol Actions
PSB-12062 is a P2X4 receptor antagonist.
PSB-12062 is a P2X4 receptor antagonist. P2X4 receptors are highly expressed in the central nervous system (CNS), and have been studied as a therapeutic target for neutopathic pain, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. PBS-12062 is a new P2X4-specific antagonist with equal potency against human, rat and mouse receptors (IC50s 1.38, 0.92 and 1.76 μM, respecitively). The compound does not display significant inhibition of human P2X1, P2X2, P2X3 or P2X7 at 10 μM.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | [S](=O)(=O)(N2c3c(cccc3)Oc4c2cccc4)c1ccc(cc1)C |
| InChI | 1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3 |
| InChI key | DHZNMEIBMACSFH-UHFFFAOYSA-N |
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¥ 2622.09
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¥ 4390.38
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