- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor.
Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.
Terameprocol is known to reduce angiogenesis1.
Preparation Note
Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to off-white |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | −20°C |
| SMILES string | COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC |
| InChI | 1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+ |
| InChI key | ORQFDHFZSMXRLM-IYBDPMFKSA-N |
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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