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N1-Methyl-Pseudo-UTP，，10427922001，Roche

销售价： ¥ 6177.68 / 件

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订货号： 0BR2851

品牌型号： Roche 10427922001

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

N1-Methyl-Pseudo-UTP (N1-Methylpseudouridine-5′-triphosphate) is a modified nucleoside triphosphate where the N1 position of pseudouridine is methylated. This modification significantly influences RNA structure and function, particularly enhancing translation efficiency and stability

Application

Scalable mRNA Synthesis: Designed for scalable mRNA production, suitable for both small-scale laboratory research and large-scale applications in biotechnology and pharmaceuticals.
Enhanced Translation Efficiency: N1-Methyl-Pseudo-UTP is used in the synthesis of mRNA to improve translation efficiency. The modified nucleotide can lead to increased protein yields in in vitro translation systems.
Stability Studies: The incorporation of N1-Methyl-Pseudo-UTP into RNA allows researchers to study the effects of nucleotide modifications on RNA stability. This application is crucial for understanding how modifications impact RNA degradation rates and half-lives.
Functional RNA Applications: The use of N1-Methyl-Pseudo-UTP in synthesizing functional RNA, such as ribozymes and RNA aptamers, can enhance their stability and functionality, making them more effective in various biological assays.
Synthetic Biology: N1-Methyl-Pseudo-UTP is utilized in synthetic biology to create RNA molecules with tailored properties, enabling the design of RNA circuits and regulatory elements with improved performance.

Features and Benefits

Improved Translation Efficiency: The methylation at the N1 position of pseudouridine enhances the interaction between mRNA and the ribosome, leading to more efficient translation and higher protein yields.
Increased Stability: RNA transcripts synthesized with N1-Methyl-Pseudo-UTP exhibit greater resistance to degradation by nucleases, resulting in longer-lasting RNA in cellular environments.
Versatile Applications: The modified nucleotide can be incorporated into various RNA synthesis protocols, making it suitable for a wide range of research applications.
Enhanced Functional Performance: The use of N1-Methyl-Pseudo-UTP in functional RNA studies can improve the performance of RNA molecules, increasing their effectiveness in biological assays.

技术参数 Specifications

form	solution
packaging	vial of 10 μmol
manufacturer/tradename	Roche 10427922001
storage temp.	−20°C

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