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Biochem/physiol Actions
Non-toxic pan ERRα/β/γ agonist with significant ERRα activity that acts as an exercise mimetic.
SLU-PP-332 is a non-toxic pan ERRα/β/γ (estrogen receptor-related receptors α/β/γ) agonist with significant ERRα activity (EC50 = 98, 230 & 430 nM against ERRα, ERRβ & ERγ) and acts as an exercise mimetic. SLU-PP-332 displays selectivity over ERα, ERβ and several other closely related nuclear receptors. It induces Ddit4 expression and enhances mitochondrial respiration in C2C12 myocytes (10 µM) and exercise endurance in mice (50 mg/kg bid, ip) in an ERRα-dependent manner.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | OC1=CC=C(C=C1)C(N/N=C/C2=CC3=C(C=C2)C=CC=C3)=O |
| InChI key | RNZIMBFHRXYRLL-XDHOZWIPSA-N |
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