- 商品介绍
- 规格参数
- 包装参数
General description
Cathepsin B, a bilobal protein, belongs to the papain-like family of cysteine proteases. It is produced as a preproenzyme. Its catalytic site is present at the interface between the two lobes. Cathepsin B has an occluding loop. It is located in the secretory vesicles of the neuronal cells. Active cathepsin B is found in the endosomal or lysosomal compartment under normal physiological conditions.
Biochem/physiol Actions
Cathepsin B is a lysosomal cysteine proteinase that metabolizes important molecules such as β-amyloid precursor protein into harmless fragments. Cathepsin B may be detected using the chromogenic substrate Z-Arg-Arg-pNA (z-arg-arg-p-nitroanalide) or flourogenic substrate Z-Arg-Arg-AMC (z-Arg-Arg-amino-4-methylcoumarin).
Cathepsin B possesses endopeptidase and exopeptidase activity. Active cathepsin B is mostly engaged in intracellular and extracellular protein turnover, which helps cells maintain homeostatic metabolic activity. It also participates in the regulation of pro-hormone and pro-enzyme activation, antigen processing, inflammatory reactions against antigens, tissue remodeling, and apoptosis. Cathepsin B plays a key role in acute pancreatitis. It also plays a vital role in lipid metabolism in atherosclerosis.
| assay | ≥95% (HPLC) |
| form | lyophilized |
| composition | Peptide Content, ≥80% |
| storage condition | protect from light |
| storage temp. | −20°C |
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¥ 4390.38
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¥ 1653.62
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¥ 20380.83
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¥ 1564.00
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¥ 2406.69
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¥ 2888.88
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¥ 145427.01
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¥ 14985.93
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¥ 17652.29
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¥ 51018.02
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¥ 65710.50
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¥ 41825.84
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