- 商品介绍
- 规格参数
- 包装参数
General description
Anti-MLK3 Antibody detects endogenous levels of total MLK3 protein.
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) or mixed lineage kinase 3 (MLK3) possesses an amino-terminal Src-homology-3 (SH3) domain followed by a kinase domain, a leucine-zipper region, a Cdc42/RAC interacting motif (CRIB) and a carboxy terminal proline/serine/threonine-rich domain. The gene encoding this serine/threonine protein kinase is localized on human chromosome 11q13.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human MLK3.
Immunogen Range: 640-689
Biochem/physiol Actions
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11), also known as mixed lineage kinase 3 (MLK3), phosphorylates c-Jun N-terminal kinases. It acts as a modulator of the mitogen-activated protein kinase (MAPK) pathway. The protein is associated with various cancers.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 92 kDa |
| species reactivity | human, rat, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:20000,immunohistochemistry: 1:50-1:100 |
| NCBI accession no. | Q16584 |
| UniProt accession no. | Q16584 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MAP3K11(4296) |
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