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Biochem/physiol Actions
Eltrombopag is an orally active nonpeptide thrombopoietin receptor (TpoR) agonist that selectively induces STAT activation and proliferation (EC50 = 270 & 30 nM, respectively) of hToR-transfected, but not non-transfected, BAF3 cells. Eltrombopag increases the differentiation of primary human CD34(+) bone marrow cells into CD41(+) megakaryocytes ex vivo (EC50 = 100 nM) and exhibits thrombopoietic activity in chimpanzees in vivo (10 mg/kg/day p.o.).
Orally active, potent and selective thrombopoietin (Tpo) receptor (TpoR) agonist in vitro and in vivo.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | faint yellow to dark orange |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | OC1=C(C=CC=C1N/N=C2C(C)=NN(C/2=O)C3=CC(C)=C(C=C3)C)C4=CC=CC(C(O)=O)=C4 |
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¥ 629.40
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¥ 807.83
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¥ 67162.32
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¥ 51018.02
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