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Biochem/physiol Actions
SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling.
potent and selective ligand of ABHD5 that activates ATGL by dissociating ABHD5 from PLIN1 and PLIN5
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | CN1C(C(C=CC=C2)=C2SC3=C1C=C(NC(NCCCC)=O)C=C3)=O |
| InChI | 1S/C19H21N3O2S/c1-3-4-11-20-19(24)21-13-9-10-17-15(12-13)22(2)18(23)14-7-5-6-8-16(14)25-17/h5-10,12H,3-4,11H2,1-2H3,(H2,20,21,24) |
| InChI key | UGYXUEPBYOKNOL-UHFFFAOYSA-N |
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¥ 2707.32
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¥ 1148.92
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¥ 1259.40
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¥ 1302.89
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¥ 2869.87
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