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Biochem/physiol Actions
Potent and subtype selective agonist at α3GABAA receptors
TP003 is a potent and subtype selective agonist at α3 GABAA receptors that exhibits an anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety. Also it appears that TP003 have anxiolytic properties but lacks ataxic, hyperphagic, and pronounced sedative effects characteristic of classical benzodiazepines in monkeys. TP003 is consider as α3-over-α1 selective positive allosteric modulator (PAM) at GABBAAR.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
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