氟桂嗪 二盐酸盐,10G,F8257-10G,Sigma

销售价: ¥ 4239.75 / 件
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订货号 0BQ5570
品牌型号 Sigma F8257-10G
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.


Application

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.


Biochem/physiol Actions

阻断 T 型 Ca2+/Na+ 通道。
阻断 T 型 Ca2+/Na+ 通道;抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。


Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


技术参数 Specifications
Quality Segment200
assay≥98% (TLC)
originatorJohnson & Johnson
storage temp.2-8°C
SMILES stringCl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI keyRXKMOPXNWTYEHI-RDRKJGRWSA-N
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