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Biochem/physiol Actions
dTRIM24, a conjugate of IACS-9571 a TRIM24 bromodomain ligand and VL-269 a VHL E3 ubiquitin ligase ligand, is a selective bifunctional degrader of bromodomain-containing transcriptional regulator TRIM24 (transcriptional intermediary factor 1a). dTRIM24 induces rapid and sustain proteasome degradation of TRIM24 in 293FT cells.
selective bifunctional degrader of bromodomain-containing transcriptional regulator TRIM24
| ligand | VL-269 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | O=C(N1C)N(C)C2=C1C=C(OC3=CC=CC(OCCC)=C3)C(NS(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)=CC=C4)(=O)=O)=C2 |
| InChI key | QUQTXFIMYFMULC-OGOZKGDESA-N |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 2528.88
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¥ 2290.21
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¥ 1683.78
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¥ 1563.36
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¥ 2013.69
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¥ 1653.62
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¥ 2882.02
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¥ 745.60
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¥ 3852.13
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¥ 4020.77
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¥ 10685.48
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¥ 5804.96
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