ADX71743，25MG，SML1829-25MG，Sigma

Biochem/physiol Actions

ADX71743 is a brain-penetrant, selective and potent negative allosteric modulator of metabotropic glutamate receptor 7 (mGlu7).
ADX71743 is a brain-penetrant, selective and potent negative allosteric modulator of metabotropic glutamate receptor 7 (mGlu7). In one study ADX71743 exhibited an anxiolytic-like profile in rat and mouse models without causing impairment of locomotor activity. In another study it induced absence epileptic seizures and lethargy.
ADX71743 is known to negatively regulate the effect of mGlu7 (metabotropic glutamate receptor subtype 7), which is associated with a number of anxiety disorders.