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General description
Alzheimer′s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
Biochem/physiol Actions
This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1).
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| biological source | (Human) |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| mol wt | 280739Da |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50~100,western blot: 1:1000,western blot: 1:500-1:2000 |
| isotype | IgG |
| NCBI accession no. | P49769, Q8HXW5,P97887 |
| storage temp. | -10 to -25°C |
| target post-translational modification | unmodified |
| Gene Information | human ... PSEN1(5663) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 2528.88
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¥ 1259.40
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¥ 1779.22
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¥ 1724.25
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¥ 5725.45
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¥ 5061.38
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